Ibutamoren MK677

Ibutamoren (MK-677) is an orally active, non-peptide growth hormone secretagogue that functions as a potent agonist of the ghrelin receptor (GHS-R1a). It has been widely studied for its ability to increase circulating levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), along with its effects on sleep architecture, lean body mass, and metabolic pathways in non-clinical and investigational research settings.

Research Focus Areas

• Stimulation of GH and IGF-1 Secretion
  MK-677 has been shown to significantly increase GH and IGF-1 levels in controlled studies(https://pmc.ncbi.nlm.nih.gov/articles/PMC2757071/). A 12-month randomized trial demonstrated improved GH secretion and increased lean body mass.
• Sleep Architecture Modulation
  In controlled environments(https://en.wikipedia.org/wiki/Ibutamoren), MK-677 has been observed to increase REM sleep duration and deep-stage (slow wave) sleep, contributing to improved overall sleep quality.
• Body Composition Outcomes
  Research trials have reported an increase in fat-free mass following MK-677 administration without significant increases in visceral or subcutaneous fat.
• Bone Metabolism Support
  MK-677 has been associated with elevated markers of bone formation and resorption, suggesting a potential effect on bone turnover and mineral density.

Potential Observations in Research

• Appetite Modulation
  MK-677 may increase appetite through ghrelin receptor stimulation. This has been reported in multiple investigational environments.
• Water Retention
  Mild water retention has been documented in some studies as a transient effect during exposure periods.
• Metabolic Considerations
  Some studies suggest that MK-677 may influence insulin sensitivity, warranting caution and continued investigation in metabolic-related research.

Handling and Dosage Information

Typical research concentrations range from 10–30 mg/mL. Volume and method of administration should be determined by the specific study protocol. While sublingual delivery has been used in some experimental settings to assess absorption characteristics, it is not required for all research methodologies.

Important Notice:
This product is intended for laboratory research use only. It is not intended for human consumption, medical, veterinary, or household use. Keep out of reach of children.

FDA Disclaimer: The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. All products are for laboratory developmental research USE ONLY. Products are not for human consumption.

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